Document
Metadata
Category
Medical and Health Sciences
Authors
Ahmed Ismail Mohamed, Jama Mohamed, Mustafe Mohamed Hussien, Hussein Mohamoud Nour, Abdulahi Abdiwali Mahamed, Ahmed Ibrahim Farah
Title
Effect of Khat (Catha edulis) chewing on liver function markers among healthy males: a comparative cross-sectional study
Journal
Pan African Medical Journal
Year of Publication
2026
DOI
doi: 10.11604/pamj.2026.53.27.49553
Abstract
Introduction: Khat (Catha edulis) chewing is a prevalent practice in Somaliland, yet its impact on liver function among metabolically healthy males remains inadequately understood. This study aims to evaluate the effects of chronic Khat chewing on liver function markers in the Somaliland population. Methods: a comparative cross-sectional study was conducted in Somaliland from January to March, 2024. A sample of apparently healthy males, consisting of habitual Khat chewers and non-chewers, was selected using purposive sampling and convenience sampling techniques, respectively. Liver function markers analyzed included total bilirubin, total protein, albumin, and glutamate pyruvate transaminase (GPT). Data were analyzed using descriptive statistics and inferential tests to compare the two groups, with significance set at p < 0.05. Results: chronic Khat chewers exhibited higher total bilirubin levels (p = <0.001) and lower total protein levels (p = <0.001) compared to non-chewers, suggesting potential hepatotoxic effects. No significant differences were observed in the serum levels of albumin and GPT between the two groups. Conclusion: chronic Khat chewing is associated with significant alterations in liver function markers, particularly elevated total bilirubin and reduced total protein levels, indicating potential hepatotoxic effects. However, albumin and GPT levels remained unaffected. Public health authorities should implement educational campaigns to raise awareness about the potential adverse effects of Khat on liver health. Healthcare providers should consider monitoring liver function markers in habitual Khat chewers as part of routine health assessments.